After reviewing the sites and applications I use most in conjunction with Twitter, I discovered it was more than I thought. I use the Twitter Home page, HootSuite, Tweetie, Bit.ly, Facebook, Twitter API, and probably a couple more every now and then. I then reviewed how and why I used each one and this process helped me considerably.
Each one of these systems has a place in my work and comfort zones and there is no reason for me to change what works well for me.
I think too many people try to force themselves to use one system, use what works the best for you!